Just finished watching Nomads (1986) and Ben-Hur (1959)...

Just finished watching Gundam Wing: Endless Waltz (1998) and Jumanji: Welcome To The Jungle (2017)...

Millions of Americans suffer from Chronic Fatigue Syndrome

A campaign is drawing attention to a a medical condition that affects people worldwide.

PEA + Luteolin – Young Nutraceuticals

https://youngnutra.com/pages/pea-luteolin

Luteolin is a bioflavonoid that neutralizes free radicals, reducing oxidative stress, which is held to be associated with aging. It is naturally occurring in many foods including artichoke, celery, parsley and peanuts.  

Like PEA, luteolin has several mechanisms of action. It inhibits mast cells, as well as mast cell-dependent T cell activation. Luteolin modulates microglial activation and inhibits pro-inflammatory cytokine production.  It also acts on GABA and opioid receptors in the spinal cord.

The combination of PEA with luteolin has been shown to decrease mast cell activation significantly more than PEA or luteolin alone, and to reduce pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6) and chemokines (MIP-1 alpha, MIP-2) significantly more than PEA or luteolin alone. Additionally, PEA with luteolin was shown to reduce oxidative and nitrosative damage more effectively than PEA or luteolin alone.

Now listening to Exploration 84 by Waveshaper and The Dark by Metal Church...

On Broadway in Vancouver. Spring of 2019.

Broadway is a major east-west thoroughfare in the city of Vancouver, British Columbia, Canada. In Vancouver’s numbered avenue grid system, it runs in place of a 9th Avenue, between 8th and 10th. The street has six lanes for most of its course. Portions of the street carry the British Columbia Highway 7 designation.

The route begins as “West Broadway” at the intersection of Wallace Crescent and 8th Avenue, in the affluent residential neighbourhood of West Point Grey, a few kilometres east of the University of British Columbia (UBC). Past Alma Street, Broadway takes over from 10th Avenue as one of Vancouver’s major thoroughfares, as it enters Greek West Broadway (or Greektown) section of Vancouver’s Kitsilano district. East of here are several blocks of generally trendy, upscale shops interspersed with low-rise apartment blocks and small supermarkets. The surrounding neighbourhoods generally consist of large, older homes dating from the early twentieth century, many of which have been subdivided into rental suites.

As Broadway approaches Arbutus Street, the commercial establishments become larger before transitioning into a mix of small to mid-size apartment blocks. East of Burrard Street, the apartment blocks get progressively taller, and commercial establishments larger and busier. Between Burrard and Main Street, Broadway can be considerably congested by vehicular traffic. Past Granville Street, Broadway yields completely to medium-to-large commercial structures and high-rise apartments and condominiums. Between Cambie and Main, the commercial establishments become smaller and somewhat more downscale.

At Ontario Street, two blocks west of Main, the route becomes “East Broadway.” After bisecting Main and Kingsway, traffic on Broadway eases somewhat, and the character returns to a mix of small-to-medium apartment buildings and commercial establishments, interspersed with older homes – all considerably less affluent than those to the west. At Commercial Drive, Broadway passes by the Commercial–Broadway SkyTrain Station. Past here for several blocks, the neighbourhood consists predominantly of older residential homes.

As Broadway travels east of Renfrew Street, the neighbourhood once again becomes mixed, with older homes to the north and larger industrial, commercial, and warehouse establishments to the south. Broadway finally ends at Cassiar Street, just short of the Vancouver-Burnaby boundary, where it becomes the Lougheed Highway.

Broadway was created at the turn of the 20th century, along with other gridded roads south of False Creek, to meet the needs of an expanding population in Vancouver. The name of the route was changed from 9th Avenue to Broadway in 1909, at the behest of merchants around Main Street (at that time the hub of Vancouver commerce), who felt that it bestowed a more cosmopolitan air. Commercial establishments originally spread out around the intersections of Cambie and Main Streets, while the character of the rest of the route remained predominantly single-family dwellings.

By the 1970s, the length of Broadway had become a major arterial route in Vancouver, conveying commuters from downtown to the neighbourhoods of the west and east sides. With the growth of UBC and the expansion of the Vancouver General Hospital (one block south of Broadway between approximately Oak and Cambie), traffic demands accelerated. In the 1990s, the agency then responsible for public transit in Greater Vancouver — BC Transit — introduced an express bus route, the 99 B-Line, to help reduce congestion. The Vancouver transportation plan for Broadway notes that congestion is such that the bus service is at capacity, and will not be eased until a new rapid transit line is built paralleling the street. It is anticipated that the SkyTrain’s Millennium Line will be extended to Central Broadway by 2021; the extension is expected to connect with Canada Line at Broadway-City Hall Station, at the intersection of Broadway and Cambie Street.

 

Palmitoylethanolamide (PEA) Nootropic Review: Benefits, Side Effects & Dosage

https://nootropicology.com/palmitoylethanolamide-pea/

Palmitoylethanolamide (PEA) is a unique nootropic that can help people with ADHD, anxiety disorders, and depression. It has also been shown to improve memory in animal studies.

What is Palmitoylethanolamide (PEA)?

Palmitoylethanolamide, or PEA, is made in the body naturally to alleviate pain and inflammation. Many plants and animals also synthesize PEA like:

- Soy lecithin
- Soybeans
- Egg yolk
- Peanuts

... and alfalfa are all high producers of PEA.

Since its discovery in the 1950s, scientists have been interested in PEA. It has potential as a pain reliever, but there is a lack of large-scale safety and efficacy data.

Nonetheless, PEA has also been found to have anti-inflammatory properties, which is why it's often used in supplements for people who are diagnosed with arthritis or other inflammatory conditions.

Palmitoylethanolamide (PEA) has also been found to work on the cannabinoid receptors in the brain, which is why it has become increasingly popular in the biohacking-sphere.

The fact that Palmitoylethanolamide (PEA) has been shown to work on the cannabinoid receptors, is the reason for its anxiolytic, antidepressant, and cognitive effects.

Palmitoylethanolamide's Mechanism of Action

PEA activates the energy-boosting, fat-burning, and anti-inflammatory PPAR alpha.

PEA inhibits pro-inflammatory genes and the synthesis of numerous inflammatory chemicals by activating this important protein.

PEA activates the bliss gene, FAAH, which degrades natural anandamide.

This results in increased amounts of soothing anandamide in your system, allowing you to relax and feel better.

It may also activate cannabinoid receptors (CB2 and CB1).

The palmitic acid in PEA might be the basis for its synthesis. The body's starting point for PEA production is saturated fatty acids.

It has also been claimed that consuming extra palmitic acid or other dietary fats will not boost PEA creation in the body. This is because your body only uses PEA when it is needed to relieve inflammation or pain, and its levels vary considerably throughout the day.

The most effective approach to get PEA's advantages is to use standardized supplements or PEA-rich meals, according to researchers.

Their idea remains in the realm of hypothesis at this time.

Benefits of Palmitoylethanolamide (PEA)

One study found that PEA can reduce chronic neuropathic pain by influencing neurotransmitter signaling.

This is mainly due to its anti-inflammatory properties, which help with managing inflammatory conditions like arthritis and other diseases.

It can also be used as a supplement for people who are dealing with symptoms of depression or anxiety.

PEA has also been shown to improve memory, learning, and brain processing in animals.

It may do this by increasing the release of dopamine from neurons involved in cognition-related processes like motivation and attentional control.

This is why it has become increasingly popular for people who take Nootropics and want to improve their focus and attention spans.

PEA's effects on these neural circuits resemble those of conventional ADHD medications.

PEA has also been shown to be effective in analgesic in rats.

It was found to work on the mu-opioid receptor, which is thought to be responsible for its painkilling effects.

At this time, there isn't enough research to determine whether it has similar effects in humans.

Many other benefits of Palmitoylethanolamide (PEA) are just beginning to be discovered.

Let's take a closer look at each benefit below...

Pain Relief

Palmitoylethanolamide (PEA) is an anti-inflammatory agent with analgesic effects.

It has been used in different types of pain management, including nerve and muscle aches.

This may be due to its ability to influence neurotransmitter signaling at the spinal level by activating descending inhibitory pathways that block the transmission of pain signals.

PEA also reduces chronic neuropathic pain by influencing neurotransmitter signaling.

It does this primarily through its anti-inflammatory properties, which are beneficial for managing inflammatory conditions like arthritis and other diseases.

Brain Health and Regeneration

Palmitoylethanolamide (PEA) may even be able to promote the growth of new neurons.

It can do this by activating PPAR alpha, which is a protein that encourages cell differentiation and regeneration in different parts of your body.

This also makes it useful for people who want to improve their memory or reduce cognitive decline.

PEA has been shown to have a positive effect on cognitive abilities in animals with dementia-like symptoms from neurodegenerative disorders or brain injury.

This is thought to be due to its ability to improve memory, learning, and the processing of stimuli by increasing dopamine output from neurons involved in cognition-related processes like motivation and attentional control.

PEA's effect on these neural circuits is similar to the effects of conventional ADHD medications.

Hormone Regulation

Palmitoylethanolamide (PEA) also regulates many hormones in your body.

It can do this by either increasing or decreasing the production of certain hormones, depending on what is needed for a given situation.

For example, it has been shown to reduce cortisol levels when they are elevated due to stress and fatigue.

This means that PEA may help improve sleep quality and provide energy to deal with stress.

On the other hand, it increases insulin production in diabetics who have hyperglycemia by reducing glucagon levels.

This makes PEA useful for people who are dealing with diabetes or hypoglycemia.

Symptoms of Depression And Anxiety

Palmitoylethanolamide (PEA) has been studied for its mood-elevating effects in animals.

It works by neurotransmitter signaling to activate the release of serotonin, dopamine, and GABA.

The inhibition of these chemicals is thought to be responsible for feelings of depression or anxiety which makes PEA useful as a treatment for depression and anxiety.

One study found that PEA improved symptoms of depression in mice treated with electroconvulsive therapy (ECT).

This is why more research on Palmitoylethanolamide (PEA) as an anti-depressant medication has been called for by many people who are dealing with depression.

Overall, Palmitoylethanolamide (PEA) is a very promising nootropic compound that has many positive health benefits for improving quality of life.

Side Effects of Palmitoylethanolamide (PEA)

Some people have reported that they experience mild side effects when taking PEA supplements or consuming high-fat meals with lots of palmitic acids, like indigestion and nausea.

Other side effects include:

- Muscle twitches and cramps
- Drowsiness or fatigue
- Loss of appetite

These side effects might be due to PEA's ability to activate the energy-boosting PPAR alpha protein in the body, which may also be responsible for its anti-inflammatory effects.

If you want to minimize your risk of experiencing side effects, it's best to take PEA supplements that are standardized for their active ingredient and remember to consume electrolytes.

The best way to take Palmitoylethanolamide

Palmitoylethanolamide is a fatty acid derivative.

Because it takes some time for Palmitoylethanolamide to build up in our bodies, certain effects may not be apparent right away.

The pain-relieving benefits of PEA are the most time-sensitive of its effects.

However, don't be discouraged, since many individuals have had excellent results with PEA after supplementing it for 2-4 weeks.

This implies that if you want to get the most out of Palmitoylethanolamide, you must take it regularly.

When it comes to dosage, the standard dose for Palmitoylethanolamide is 400 mg-800mg, twice a day.

To maximize absorption, you should time your supplement intake with meals that contain dietary fats.

In Summary

Palmitoylethanolamide (PEA) is a fatty acid derivative that has been studied for its mood-elevating effects in animals.

It works by neurotransmitter signaling to activate the release of serotonin, dopamine, and GABA.

The inhibition of these chemicals is thought to be responsible for feelings of depression or anxiety which makes PEA useful as a treatment for depression and anxiety.

Palmitoylethanolamide (PEA) is best taken regularly and at a dose of 400-800 mg, twice per day.

Finally, remember to take PEA supplements with meals that contain dietary fats for maximum absorption.